Placental infarction leading to fetal or neonatal death. A prospective study

Obstet Gynecol. 1977 Nov;50(5):583-8.


The pathogenesis of perinatal death due to placental infarction was analyzed in a large prospective study that included more than 1000 medical, demographic, hereditary, and postmortem variables. The disorder was the fifth most frequent cause of death in the study with a perinatal mortality of 2.26/1000 births. Its frequency was directly correlated with the gravidas' blood pressures, an effect augmented by albuminuria and work during pregnancy. Fatal infarcts were increased 20-fold with glomerulonephritis, fivefold with abruptio placentae, and twofold when the gravidas' hemoglobins were over 12 g/100 ml. Maternal weight gains were suboptimal and the involved neonates had a pattern of growth retardation characteristic of undernutrition. The disorder was more frequent when the gravida had made few prenatal visits for medical care and had had prior unsuccessful pregnancies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abruptio Placentae / complications
  • Adolescent
  • Adult
  • Albuminuria / complications
  • Blood Pressure
  • Body Weight
  • Child
  • Female
  • Fetal Death / etiology*
  • Fetus / physiology
  • Growth
  • Humans
  • Infant Mortality*
  • Infant, Newborn
  • Infarction / complications*
  • Pennsylvania
  • Placenta / blood supply*
  • Pregnancy
  • Prospective Studies