Effect of increased bromide intake on iodine excretion in rats

Biol Trace Elem Res. 1996 Dec;55(3):215-9. doi: 10.1007/BF02785280.

Abstract

The time course of iodine excretion in adult male rats substantially differs from bromine excretion. Bromine is excreted at a single rate, whereas iodine evinces two excretion rates. Even a strong increase in bromide intake in experimental animals failed to affect the rate of iodine excretion but it lowered the fraction of iodine accumulated in the thyroid gland by 20% probably by affecting the transport of iodide into the thyroid gland.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bromides / administration & dosage
  • Bromides / pharmacology*
  • Bromine / metabolism*
  • Half-Life
  • Injections, Subcutaneous
  • Iodine / metabolism*
  • Iodine Radioisotopes
  • Isotope Labeling
  • Male
  • Radionuclide Imaging
  • Rats
  • Rats, Wistar
  • Thyroid Gland / diagnostic imaging
  • Thyroid Gland / metabolism*
  • Whole-Body Counting

Substances

  • Bromides
  • Iodine Radioisotopes
  • Iodine
  • Bromine