Modafinil in obstructive sleep apnea-hypopnea syndrome: a pilot study in 6 patients

Respiration. 1997;64(2):159-61. doi: 10.1159/000196661.

Abstract

We studied the effects of modafinil, a vigilance-enhancing drug, on excessive daytime sleepiness, memory, night sleep and respiration in 6 patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) using a double-blind random cross-over design with 24-hour polysomnography, verbal memory test and a 5-week sleep-wake diary kept by the patients. There were two 2-week treatment periods in which either modafinil or placebo was used; they were separated by a 1-week wash-out period. Our results show that modafinil reduces daytime sleep duration, lengthens the duration of subjective daytime vigilance and improves long-term memory in patients with OSAHS without modifying night sleep and respiration events.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Benzhydryl Compounds / therapeutic use*
  • Central Nervous System Stimulants / therapeutic use*
  • Cross-Over Studies
  • Double-Blind Method
  • Humans
  • Male
  • Memory / drug effects
  • Middle Aged
  • Modafinil
  • Pilot Projects
  • Polysomnography
  • Sleep Apnea Syndromes / drug therapy*
  • Sleep Apnea Syndromes / physiopathology
  • Sleep Stages / drug effects

Substances

  • Benzhydryl Compounds
  • Central Nervous System Stimulants
  • Modafinil