Superior limbic keratoconjunctivitis. A prognostic sign for severe Graves ophthalmopathy

Ophthalmology. 1995 Oct;102(10):1472-5. doi: 10.1016/s0161-6420(95)30843-3.


Purpose: To study superior limbic keratoconjunctivitis in a relatively large group of patients and to determine whether a relation exists with thyroid dysfunction.

Methods: The medical records of 57 patients with superior limbic keratoconjunctivitis who were examined between 1980 and 1993 were reviewed.

Results: Thirty-seven patients (64.9%; 95% confidence interval, 51.1-77.1) had objective evidence of thyroid dysfunction. Of patients with superior limbic keratoconjunctivitis and thyroid disease, 33 (89.2%) had ophthalmopathy, which in 16 patients (48.5%) was sufficiently severe to require orbital decompression.

Conclusion: Superior limbic keratoconjunctivitis is associated with thyroid dysfunction and appears to be a prognostic marker for severe Graves ophthalmopathy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Eyelid Diseases / complications
  • Eyelid Diseases / diagnosis*
  • Female
  • Follow-Up Studies
  • Graves Disease / complications
  • Graves Disease / diagnosis*
  • Humans
  • Keratoconjunctivitis / complications
  • Keratoconjunctivitis / diagnosis*
  • Male
  • Middle Aged
  • Prognosis