Comparative study of brain magnetic resonance imaging findings in patients with low-tension glaucoma and control subjects

Ophthalmology. 1995 Nov;102(11):1632-8. doi: 10.1016/s0161-6420(95)30816-0.


Purpose: To evaluate the presence of central nervous system degeneration in patients with low-tension glaucoma using magnetic resonance imaging.

Method: Ten patients with low-tension glaucoma and ten age-matched control subjects underwent magnetic resonance imaging. Cortical atrophy and cerebral infarcts were graded from "0" (normal) to "3," which was done subjectively by two neuroradiologists independently in a masked fashion. Midsagittal corpus callosum section was evaluated by measuring the thickness and cross-sectional area.

Results: There was a significantly greater extent of cerebral infarcts in the patients with low-tension glaucoma (P = 0.02). The thickness of the body (P = 0.03) and genu (P = 0.04) of the corpus callosum were thinner in the patients with low-tension glaucoma. The corpus callosum cross-sectional area was smaller in the low-tension glaucoma group (P = 0.04). There were no significant differences in the other parameters in this study.

Conclusion: This study suggests a greater extent of cerebral infarcts and corpus callosum atrophy in patients with low-tension glaucoma. This may imply a greater degree of neuronal degeneration, possibly on an ischemic basis in low-tension glaucoma.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain / pathology*
  • Cerebral Infarction / complications
  • Cerebral Infarction / diagnosis*
  • Corpus Callosum / pathology
  • Female
  • Glaucoma / complications*
  • Humans
  • Intraocular Pressure
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Prevalence
  • Visual Acuity