Ocular hypertension and central corneal thickness

Ophthalmology. 1995 Dec;102(12):1810-2. doi: 10.1016/s0161-6420(95)30790-7.


Purpose: To determine whether ocular hypertension (OHT) is over diagnosed in patients with increased corneal thickness.

Methods: Thirty-six patients with OHT were compared with 29 control subjects and 31 patients with glaucoma. Corneal thickness was determined by ultrasonic pachymetry and measured at a single point, 1.5 mm temporal to the corneal light reflex.

Results: The corneal thickness (mean +/- standard deviation) in patients with OHT was 0.610 +/- 0.033 mm. This was significantly greater than in patients with glaucoma (0.557 +/- 0.039 mm) and control subjects (0.567 +/- 0.036 mm).

Conclusion: It is well documented that increased corneal thickness leads to artificially high estimations of intraocular pressure. This study confirms that a significant number of patients with OHT have a normal intraocular pressure if corneal thickness is taken into account. Corneal pachymetry is clinically helpful in estimating intraocular pressure, determining the risk of visual loss, and establishing a target pressure.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cornea / diagnostic imaging
  • Cornea / pathology*
  • Female
  • Glaucoma / diagnosis*
  • Humans
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Ocular Hypertension / diagnosis*
  • Ultrasonography