Single intraoperative application versus postoperative mitomycin C eye drops in pterygium surgery

Ophthalmology. 1995 Dec;102(12):1949-52. doi: 10.1016/s0161-6420(95)30770-1.

Abstract

Purpose: To determine the minimum effective dosage, most effective route of administration and long-term effects of mitomycin C for prevention of recurrence after pterygium surgery.

Methods: In a prospective, masked study, 227 patients undergoing surgery for primary pterygia were assigned randomly to five groups: group 1 received a single intraoperative application of 0.2 mg/ml mitomycin C for 3 minutes; group 2 received a single intraoperative application of 0.4 mg/ml mitomycin C for 3 minutes; group 3 received mitomycin C eye drops 0.2 mg/ml three times daily for 7 days; group 4 received mitomycin C eye drops 0.4 mg/ml three times daily for 14 days; group 5 acted as a control (surgery alone).

Results: After a mean follow-up time of 28 months, recurrence rates of 6.66%, 4.08%, 4.26%, 4.44%, and 29.27%, respectively, were observed. Statistical analysis showed significant differences between groups receiving mitomycin C and the control (P < or = 0.001). There was no statistical difference among treated groups (P > or = 0.0681). No complications of therapy were observed.

Conclusion: These results support the efficacy and relative safety of a single, low-concentration, intraoperative application of mitomycin C in pterygium surgery together with the use of a conjunctival flap, avoiding excessive cauterization of the sclera and leaving bare sclera.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antibiotics, Antineoplastic / administration & dosage*
  • Antibiotics, Antineoplastic / adverse effects
  • Conjunctiva / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Intraoperative Care
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage*
  • Mitomycin / adverse effects
  • Ophthalmic Solutions
  • Postoperative Care
  • Prospective Studies
  • Pterygium / drug therapy*
  • Pterygium / prevention & control
  • Pterygium / surgery*
  • Recurrence
  • Safety
  • Surgical Flaps
  • Treatment Outcome

Substances

  • Antibiotics, Antineoplastic
  • Ophthalmic Solutions
  • Mitomycin