Genetics of drug resistance in tuberculosis

Clin Chest Med. 1997 Mar;18(1):55-64. doi: 10.1016/s0272-5231(05)70355-5.


In the last few years, there has been considerable progress in our understanding of the mechanisms of action and resistance to antimycobacterials. To date, there is information about 11 genes involved in resistance in M. tuberculosis. This has prompted the development of novel tests for the rapid identification of resistant strains, and has provided invaluable insight into unique mycobacterial structures, which are important targets for the development of new inhibitory compounds.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antitubercular Agents / pharmacology
  • Drug Resistance, Microbial / genetics*
  • Drug Resistance, Multiple
  • Humans
  • Mutation
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / pathogenicity
  • Polymerase Chain Reaction / methods
  • Tuberculosis / diagnosis
  • Virulence


  • Antitubercular Agents