Comparison of subcutaneous apomorphine versus dispersible madopar latency and effect duration in Parkinson's disease patients: a double-blind single-dose study

Clin Neuropharmacol. 1997 Apr;20(2):165-7. doi: 10.1097/00002826-199704000-00008.


Twelve parkinsonian patients with severely fluctuating symptoms were given a single dose of apomorphine or Dispersible Madopar on 2 consecutive days, to confirm the latter drug's usefulness in "off" period rescue. According to our results, apomorphine proved faster in reverting "off" periods and should still be regarded as the drug of choice for this treatment modality.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Administration, Oral
  • Antiparkinson Agents / therapeutic use*
  • Apomorphine / therapeutic use*
  • Aromatic Amino Acid Decarboxylase Inhibitors*
  • Benserazide / therapeutic use*
  • Double-Blind Method
  • Drug Combinations
  • Enzyme Inhibitors / therapeutic use
  • Female
  • Humans
  • Injections, Subcutaneous
  • Levodopa / therapeutic use*
  • Male
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / physiopathology


  • Antiparkinson Agents
  • Aromatic Amino Acid Decarboxylase Inhibitors
  • Drug Combinations
  • Enzyme Inhibitors
  • benserazide, levodopa drug combination
  • Levodopa
  • Benserazide
  • Apomorphine