Ankylosing spondylitis: klebsiella and HL-A B27

Rheumatol Rehabil. 1977 Aug;16(3):190-6. doi: 10.1093/rheumatology/16.3.190.


A search for the presence of Klebsiella-Enterobacter spp. and Yersinia enterocolitica in urine and faeces of 63 patients with ankylosing spondylitis was conducted because these microorganisms have been demonstrated to cross-react immunologically with HL-A B27 positive lymphocytes. The patients were graded into three groups on the basis of disease activity. Klebsiella spp. were found in the faeces of 13 (93%) of the 14 patients with 'active' disease, 10 (48%) of the 21 patients with 'probably active' disease and in one (4%) of the 28 patients with 'inactive' disease. Positive cultures were also obtained in 47 (38%) of 124 controls. It is suggested that the presence of Klebsiella spp. in faecal cultures may be associated with 'active' disease in patients with ankylosing spondylitis.

MeSH terms

  • Adult
  • Enterobacter / metabolism
  • Feces / microbiology
  • Female
  • HLA Antigens*
  • Humans
  • Klebsiella / immunology
  • Klebsiella / metabolism*
  • Male
  • Spondylitis, Ankylosing* / immunology
  • Spondylitis, Ankylosing* / metabolism
  • Spondylitis, Ankylosing* / microbiology
  • Urine / microbiology
  • Yersinia / metabolism


  • HLA Antigens