Endotoxin shock-associated hypothermia. How and why does it occur?

Ann N Y Acad Sci. 1997 Mar 15;813:733-7. doi: 10.1111/j.1749-6632.1997.tb51775.x.


In sum, our results indicate that LPS shock-associated hypothermia involves the following major mechanisms: 1) a decrease in the threshold Tb for activation of cold thermogenesis; 2) the resultant widening of the interthreshold zone; and 3) cold-seeking behavior. We speculate that, in severe systemic inflammation, this hypothermia constitutes an adaptive response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure
  • Body Temperature Regulation* / drug effects
  • Hypothalamus / physiology
  • Hypothermia / etiology*
  • Lipopolysaccharides / toxicity
  • Oxygen Consumption
  • Rats
  • Rats, Wistar
  • Shock, Septic / physiopathology*
  • Skin / blood supply
  • Vasodilation


  • Lipopolysaccharides