Dietary sucrose and starch affect dysplastic characteristics in carcinogen-induced aberrant crypt foci in rat colon

Cancer Lett. 1997 Mar 19;114(1-2):39-41. doi: 10.1016/s0304-3835(97)04620-x.

Abstract

To study whether dietary carbohydrates affect dysplasia in aberrant crypt foci (ACF), rats treated with 1,2-dimethilhydrazine (DMH) were fed for three months with diets containing 46% sucrose or corn starch. The number of ACF/colon in the two dietary groups was similar (P = 0.58), but ACF were smaller in the starch than in sucrose group (P < 0.05). ACF in the starch group also showed less severe goblet cell dysplasia, more sulphomucins and less sialomucins than in the sucrose group (P < 0.05), indicating that corn starch protects against colon carcinogenesis while sucrose in the diet is detrimental, promoting the dysplasia of preneoplastic lesions like ACF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1,2-Dimethylhydrazine
  • Animals
  • Carcinogens
  • Colonic Neoplasms / prevention & control*
  • Dietary Sucrose / therapeutic use*
  • Dimethylhydrazines
  • Female
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / pathology
  • Mucins / biosynthesis
  • Mucins / chemistry
  • Precancerous Conditions / chemically induced
  • Precancerous Conditions / pathology*
  • Precancerous Conditions / prevention & control
  • Rats
  • Rats, Sprague-Dawley
  • Starch / therapeutic use*

Substances

  • Carcinogens
  • Dietary Sucrose
  • Dimethylhydrazines
  • Mucins
  • Starch
  • 1,2-Dimethylhydrazine