Measurement and metabolism of isoflavonoids and lignans in the human male

Cancer Lett. 1997 Mar 19;114(1-2):145-51. doi: 10.1016/s0304-3835(97)04646-6.


Asian men, who consume a low fat/high fibre soya-based diet, have very much lower incidence of prostate cancer than men from North America and Europe. The soya bean is a rich source of the isoflavonic phyto-oestrogens, daidzein, genistein and equol, compounds which may be cancer-protective in Asian populations. The lignans, enterolactone and enterodiol, plant oestrogens derived from cereals and vegetables, may act in a similar manner in vegetarian men. We report here on the measurement of isoflavonoids and lignans, by gas chromatography-mass spectrometry, in prostatic fluid of men from Asia and Europe and also on the metabolism of these compounds in Western men following dietary supplementation.

MeSH terms

  • Adult
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Isoflavones / analysis*
  • Isoflavones / metabolism*
  • Lignans / analysis*
  • Lignans / metabolism*
  • Linseed Oil / metabolism*
  • Male
  • Middle Aged
  • Prostate / metabolism*
  • Soybeans / metabolism*
  • Time Factors


  • Isoflavones
  • Lignans
  • Linseed Oil