Abstract
A young girl born to a mother with systemic lupus erythematosus (SLE) had congenital heart block and developed symptoms of a connective tissue disorder at the age of 13 y. When first seen at the age of 15 y she was found to have an unclassified connective tissue disorder and to be seropositive for anti Ro/SSA and U1 RNP. This constellation of clinical/serological features has not been described among the reported handful of patients with congenital heart block and subsequent development of a connective tissue disorder.
MeSH terms
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Adolescent
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Adult
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Antibodies, Antinuclear / blood
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Antibodies, Antinuclear / immunology*
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Autoantigens / immunology
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Autoimmune Diseases / genetics*
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Autoimmune Diseases / immunology
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Connective Tissue Diseases / genetics*
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Connective Tissue Diseases / immunology
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Female
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HLA Antigens / analysis
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Heart Block / congenital*
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Heart Block / immunology
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Humans
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Immunity, Maternally-Acquired
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Lupus Erythematosus, Systemic / genetics
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Pregnancy
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Pregnancy Complications / immunology
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RNA, Small Cytoplasmic*
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Raynaud Disease / etiology
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Ribonucleoprotein, U1 Small Nuclear / immunology
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Ribonucleoproteins / immunology
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Scleroderma, Localized / etiology
Substances
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Antibodies, Antinuclear
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Autoantigens
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HLA Antigens
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RNA, Small Cytoplasmic
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RO60 protein, human
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Ribonucleoprotein, U1 Small Nuclear
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Ribonucleoproteins
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SS-A antigen