Congenital heart block and subsequent connective tissue disorder in adolescence

Lupus. 1997;6(3):283-4. doi: 10.1177/096120339700600313.

Abstract

A young girl born to a mother with systemic lupus erythematosus (SLE) had congenital heart block and developed symptoms of a connective tissue disorder at the age of 13 y. When first seen at the age of 15 y she was found to have an unclassified connective tissue disorder and to be seropositive for anti Ro/SSA and U1 RNP. This constellation of clinical/serological features has not been described among the reported handful of patients with congenital heart block and subsequent development of a connective tissue disorder.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antinuclear / blood
  • Antibodies, Antinuclear / immunology*
  • Autoantigens / immunology
  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / immunology
  • Connective Tissue Diseases / genetics*
  • Connective Tissue Diseases / immunology
  • Female
  • HLA Antigens / analysis
  • Heart Block / congenital*
  • Heart Block / immunology
  • Humans
  • Immunity, Maternally-Acquired
  • Lupus Erythematosus, Systemic / genetics
  • Pregnancy
  • Pregnancy Complications / immunology
  • RNA, Small Cytoplasmic*
  • Raynaud Disease / etiology
  • Ribonucleoprotein, U1 Small Nuclear / immunology
  • Ribonucleoproteins / immunology
  • Scleroderma, Localized / etiology

Substances

  • Antibodies, Antinuclear
  • Autoantigens
  • HLA Antigens
  • RNA, Small Cytoplasmic
  • RO60 protein, human
  • Ribonucleoprotein, U1 Small Nuclear
  • Ribonucleoproteins
  • SS-A antigen