Abstract
Neurotoxin (AMPA)-induced lesions in the caudate nucleus as well as unilateral surgical transection of the striato-nigral pathway strongly depleted the binding of a homophthalazine (formerly called 2,3-benzodiazepines) girisopam (GYKI-51189, EGIS 5810) selectively in the substantia nigra of the rat, ipsilateral to the lesions. In contrast to this, AMPA injections into the substantia nigra failed to effect on girisopam binding to either components of the nigro-striatal system. Data indicate that this homophthalazine may bind to a descending component of the striatum (striato-nigral projecting neurons), or its binding capacity to substantia nigra neurons depends on the integrity of striatal afferent pathways to the substantia nigra.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Afferent Pathways / physiology
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Animals
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Anti-Anxiety Agents / metabolism
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Benzodiazepines / metabolism*
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Binding Sites
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Caudate Nucleus / drug effects
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Caudate Nucleus / pathology
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Caudate Nucleus / physiology*
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Globus Pallidus / drug effects
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Globus Pallidus / pathology
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Globus Pallidus / physiology*
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Male
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Neurotoxins / toxicity
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / pathology
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Nucleus Accumbens / physiology*
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Rats
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Rats, Sprague-Dawley
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Receptors, GABA-A / metabolism
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Substantia Nigra / drug effects
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Substantia Nigra / pathology
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Substantia Nigra / physiology*
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / toxicity
Substances
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Anti-Anxiety Agents
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Neurotoxins
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Receptors, GABA-A
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Benzodiazepines
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girisopam
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid