Granulocyte-macrophage colony-stimulating factor as an adjuvant in tumor immunotherapy

Med Oncol. 1996 Sep;13(3):155-60.

Abstract

Induction of specific anti-tumor immunity by active immunization has been the aim of researchers for decades. However, a generally applicable successful immunization strategy that could be used in the clinic has not yet been devised. Recent research has been directed at identifying and defining tumor-specific and tumor-associated antigens. Several good candidates are now at hand. If these antigens are to perform optimally at immunization, there is a need for proper adjuvants. This article focuses on one adjuvant, the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), and the possible application of this molecule to active specific immunotherapy.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / therapeutic use*
  • Animals
  • Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use*
  • Humans
  • Immunization / methods
  • Immunotherapy / methods*
  • Neoplasms / drug therapy*
  • Vaccination

Substances

  • Adjuvants, Immunologic
  • Granulocyte-Macrophage Colony-Stimulating Factor