Atypical MRI features of Wilson's disease: high signal in globus pallidus on T1-weighted images

Neuroradiology. 1997 Mar;39(3):171-4. doi: 10.1007/s002340050386.


Most reports of MRI in Wilson's disease have been of abnormal low-signal lesions on T1-weighted images and high signal intensity on T2-weighted images. In contrast, we report three patients who had high-signal lesions in the globus pallidus on T1-weighted images, a finding seen in patients with portal-systemic encephalopathy. The possible causes include the paramagnetic effect of copper or iron and accumulation of Alzheimer type II glial cells.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alzheimer Disease / diagnosis
  • Copper / metabolism
  • Diagnosis, Differential
  • Female
  • Globus Pallidus / pathology*
  • Hepatic Encephalopathy / diagnosis*
  • Hepatolenticular Degeneration / diagnosis*
  • Humans
  • Iron / metabolism
  • Magnetic Resonance Imaging*
  • Male
  • Mesencephalon / pathology
  • Neuroglia / pathology
  • Putamen / pathology


  • Copper
  • Iron