The role of the Caspase family of cysteine proteases in apoptosis

Semin Immunol. 1997 Feb;9(1):35-49. doi: 10.1006/smim.1996.0058.


Members of the ICE/Ced3 family are cysteine endoproteases that have been found to induce many of the proteolytic events observed during apoptosis. Because these proteases selectively recognize an Asp as the P1 residue at the cleavage site this newly emerging protease family has been called the Caspase family Cysteinyl aspartate-specific protease.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis / physiology*
  • Cysteine Endopeptidases / classification
  • Cysteine Endopeptidases / physiology*
  • Cysteine Proteinase Inhibitors
  • Enzyme Activation
  • Granzymes
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Serine Endopeptidases / metabolism
  • Signal Transduction


  • Cysteine Proteinase Inhibitors
  • Granzymes
  • Serine Endopeptidases
  • Cysteine Endopeptidases