Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy

Lancet. 1997 Apr 12;349(9058):1063-5. doi: 10.1016/S0140-6736(96)09110-6.


Background: Human parvovirus B19 replicates in erythroid precursors of the bone marrow, and several diseases have been attributed to this virus including some cases of juvenile chronic arthropathy.

Methods: Tissue samples from children with juvenile arthritis and from healthy young adults with recent joint trauma were examined for B19 DNA by PCR. We also studied the timing of the parvovirus infection serologically.

Findings: All samples of synovial fluid, bone marrow, and blood were negative for B19 DNA. Eight (28%) of the 29 children with chronic arthritis had B19 DNA in synovial tissues. However, an even higher proportion of the non-arthropathy controls were positive for B19 DNA in synovial membranes (13 [48%] of 27). All the individuals with B19 DNA in synovial membrane had serum IgG antibodies to B19.

Interpretation: Genomic B19 DNA can persist in the synovial membranes not only in patients with chronic arthropathy but also in healthy immunocompetent individuals. The diagnostic criteria for parvovirus arthropathy must be reevaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Viral / blood
  • Arthritis, Juvenile / virology*
  • Bone Marrow / virology
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Chronic Disease
  • DNA, Viral / analysis*
  • DNA, Viral / blood
  • Humans
  • Parvovirus B19, Human / immunology
  • Parvovirus B19, Human / isolation & purification*
  • Polymerase Chain Reaction
  • Synovial Membrane / virology*


  • Antibodies, Viral
  • DNA, Viral