The role of immunoproteins in the survival of liposomes in the circulation

Crit Rev Ther Drug Carrier Syst. 1997;14(2):105-31.


The clearance of liposomes from the circulation is mediated largely by the cells of the reticuloendothelial system. These cells recognize liposome-bound immunoproteins, particularly immunoglobulins and complement. This review addresses the state of knowledge of the plasma proteins that can initiate complement activation and antibody binding and the known interactions among these proteins and liposomes. Evidence for the involvement of immunoproteins and other molecules in the in vivo survival of liposomes is also reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigen-Antibody Reactions
  • Complement Activation
  • Complement System Proteins / physiology*
  • Drug Carriers
  • Humans
  • Immunoglobulins / physiology*
  • Liposomes / metabolism*
  • Metabolic Clearance Rate
  • Opsonin Proteins / physiology*


  • Drug Carriers
  • Immunoglobulins
  • Liposomes
  • Opsonin Proteins
  • Complement System Proteins