The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors

Microcirculation. 1997 Mar;4(1):1-23. doi: 10.3109/10739689709148314.


To reach cancer cells in a tumor, a blood-borne therapeutic molecule or cell must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically and then integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiologic barriers in solid tumors and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.

Publication types

  • Biography
  • Historical Article
  • Lecture
  • Portrait
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Awards and Prizes*
  • Biological Transport
  • Capillary Permeability
  • History, 20th Century
  • Humans
  • Leukocytes / physiology
  • Lymphatic System / physiology
  • Medical Oncology* / history
  • Microcirculation
  • Neoplasms / blood supply*
  • Neoplasms / drug therapy*
  • Neoplasms / physiopathology
  • Neovascularization, Pathologic
  • United States

Personal name as subject

  • R K Jain