Brodifacoum intoxication with marijuana smoking

Arch Pathol Lab Med. 1997 Jan;121(1):67-9.

Abstract

We report the case of a 17-year-old boy with a significant history of drug and alcohol abuse, which included smoking marijuana mixed with brodifacoum. As a consequence, the patient developed a prolonged coagulopathy that persisted for more than 1 year. To our knowledge, this is the first case reported in the literature in which super-warfarin intoxication has been associated with marijuana smoking. This report should increase the awareness of pathologists and clinicians when examining a patient with a history of drug abuse who exhibits persistent vitamin K1-dependent coagulopathy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Hydroxycoumarins / poisoning*
  • Adolescent
  • Blood Coagulation / drug effects*
  • Blood Coagulation Factors / analysis
  • Factor X Deficiency / chemically induced*
  • Factor X Deficiency / diagnosis
  • Factor X Deficiency / therapy
  • Humans
  • Male
  • Marijuana Smoking*
  • Prothrombin Time
  • Rodenticides / poisoning*
  • Vitamin K 1 / administration & dosage
  • Vitamin K 1 / antagonists & inhibitors

Substances

  • 4-Hydroxycoumarins
  • Blood Coagulation Factors
  • Rodenticides
  • Vitamin K 1
  • bromfenacoum