Hippocampal atrophy secondary to entorhinal cortical degeneration in Alzheimer-type dementia

Neurosci Lett. 1997 Jan 31;222(2):119-22. doi: 10.1016/s0304-3940(97)13365-1.


Pathological comparison between cases with Alzheimer-type dementia (ATD) and the non-demented cases with infarct showed that hippocampal atrophy in ATD could be caused mainly by degeneration of the stratum lacunosum-radiatum rather than neuronal loss in the pyramidal layer of the hippocampus, and that degeneration of the stratum lacunosum-radiatum could be secondary mainly to the entorhinal cortical degeneration.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / pathology*
  • Atrophy
  • Entorhinal Cortex / pathology*
  • Female
  • Hippocampus / pathology*
  • Humans
  • Nerve Degeneration / physiology*