Peripheral neuroepithelioma (peripheral primitive neuroectodermal tumor) of the uterine cervix

Tohoku J Exp Med. 1996 Oct;180(2):187-95. doi: 10.1620/tjem.180.187.


We report here a case of peripheral neuroepithelioma arising in the uterine cervix. A 44-year-old female had complained of irregular genital bleeding for several months and was diagnosed as extraosseous Ewing's sarcoma (EOE) from biopsy specimens initially. The tumor cells, which were intensely stained by periodic acid-Schiff (PAS) and digested with diastase, were uniformly small and round, had hyperchromatic nuclei and scant, indistinct cytoplasm. The surgically-removed tumor cells were immunohistochemically stained with antisera against neuro-specific enolase (NSE), tyrosine hydroxylase. In ultrastructural study, neurosecretory granules were observed. Finally we diagnosed this case as peripheral neuroepithelioma (peripheral primitive neuroectodermal tumor, PNET).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Coloring Agents
  • Cytoplasmic Granules / pathology
  • Cytoplasmic Granules / ultrastructure
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunohistochemistry
  • Neuroectodermal Tumors, Primitive, Peripheral / pathology*
  • Neuroectodermal Tumors, Primitive, Peripheral / surgery
  • Neuroectodermal Tumors, Primitive, Peripheral / ultrastructure
  • Phosphopyruvate Hydratase / analysis
  • Sarcoma, Ewing / pathology
  • Tyrosine 3-Monooxygenase / analysis
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / surgery
  • Uterine Cervical Neoplasms / ultrastructure


  • Coloring Agents
  • Tyrosine 3-Monooxygenase
  • Phosphopyruvate Hydratase