Postmortem MR imaging of the brains of patients with AIDS

Neuroimaging Clin N Am. 1997 May;7(2):297-320.


Forty-two postmortem formalin-fixed brains of known patients with AIDS were examined with T2-weighted MR imaging before brain cutting. The gross and microscopic brain findings were correlated with the T2 signal changes in the postmortem MR imaging. The brains included examples of progressive multifocal leukoencephalopathy with involvement of the central brain and cerebellum. The authors also encountered the coexistence of progressive multifocal leukoencephalopathy and HIV encephalitis, and the T2 signal changes for each were compared. The T2 signal changes of leptomeningeal and perivascular space cryptococcal infection and CMV ependymitis are documented. Several expressions of primary cerebral lymphoma, including large nodules, choroid plexus infiltration, and diffuse microscopic sites of tumor also are assessed.

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis
  • AIDS-Related Opportunistic Infections / pathology
  • Acquired Immunodeficiency Syndrome / diagnosis
  • Acquired Immunodeficiency Syndrome / pathology*
  • Adult
  • Brain / pathology*
  • Brain Diseases / diagnosis
  • Brain Diseases / pathology
  • Encephalitis, Viral / diagnosis
  • Encephalitis, Viral / pathology
  • Female
  • Humans
  • In Vitro Techniques
  • Leukoencephalopathy, Progressive Multifocal / diagnosis
  • Leukoencephalopathy, Progressive Multifocal / pathology
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged