Chromatin Remodeling and Transcription

Curr Opin Genet Dev. 1997 Apr;7(2):182-91. doi: 10.1016/s0959-437x(97)80127-x.

Abstract

Recent advances highlight two important chromatin remodeling systems involved in the transcriptional process. One system includes several members of the evolutionarily conserved SWI2/SNF2 family found in distinct multiprotein complexes with ATP-dependent nucleosome destabilizing activity; the other is the enzymatic system that governs histone acetylation and deacetylation. Identification of the catalytic subunits of these opposing histone-modifying activities reveal conserved proteins defined genetically as transcriptional regulators.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Acetyltransferases*
  • Adenosine Triphosphate
  • Animals
  • Cell Cycle Proteins / metabolism
  • Chromatin*
  • DNA / chemistry
  • DNA Helicases
  • DNA-Binding Proteins / metabolism
  • Fungal Proteins / metabolism
  • Histone Acetyltransferases
  • Histone Deacetylases / metabolism
  • Histones
  • Humans
  • Nuclear Proteins / metabolism
  • Nucleic Acid Conformation
  • Nucleosomes
  • Protein Kinases / metabolism
  • Saccharomyces cerevisiae Proteins*
  • TATA-Binding Protein Associated Factors*
  • Tetrahymena
  • Transcription Factor TFIID*
  • Transcription Factors / metabolism
  • Transcription, Genetic*
  • p300-CBP Transcription Factors

Substances

  • CHD1 protein, S cerevisiae
  • Cell Cycle Proteins
  • Chromatin
  • DNA-Binding Proteins
  • Fungal Proteins
  • Histones
  • Nuclear Proteins
  • Nucleosomes
  • SMARCA1 protein, human
  • SMARCA2 protein, human
  • Saccharomyces cerevisiae Proteins
  • TATA-Binding Protein Associated Factors
  • Transcription Factor TFIID
  • Transcription Factors
  • Adenosine Triphosphate
  • DNA
  • Acetyltransferases
  • Histone Acetyltransferases
  • p300-CBP Transcription Factors
  • p300-CBP-associated factor
  • Protein Kinases
  • TATA-binding protein associated factor 250 kDa
  • Histone Deacetylases
  • SMARCA4 protein, human
  • DNA Helicases
  • CHD1 protein, human