Deconstructing the Nucleus: Global Architecture From Local Interactions

Curr Opin Genet Dev. 1997 Apr;7(2):259-63. doi: 10.1016/s0959-437x(97)80136-0.


Recent advances in fluorescence in situ hybridization and three-dimensional microscopy have revealed a high degree of large-scale order in the nucleus, indicating that the position of each gene within the nucleus is not random. As with any other biological phenomenon, this large-scale organization must ultimately be specified by molecular interactions. Biochemical and molecular investigations have revealed a small set of local molecular-scale interactions that can be used together in a combinatorial fashion to establish a global large-scale nuclear architecture.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus* / genetics
  • Cell Nucleus* / physiology
  • Chromatin
  • Chromosomes*
  • Forecasting
  • Humans


  • Chromatin