Life and death in the cytoplasm: messages from the 3' end

Curr Opin Genet Dev. 1997 Apr;7(2):220-32. doi: 10.1016/s0959-437x(97)80132-3.


The cytoplasmic life of an mRNA revolves around the regulation of its localization, translation and stability. Interactions between the two ends of the mRNA may integrate translation and mRNA turnover. Regulatory elements in the region between the termination codon and poly(A) tail - the 3' untranslated region - have been identified in a wide variety of systems, as have been some of the key players with which these elements interact.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytoplasm
  • Humans
  • Mutation
  • Poly A
  • Protein Biosynthesis
  • RNA, Messenger*
  • Regulatory Sequences, Nucleic Acid*
  • Transcription Factors
  • Yeasts


  • RNA, Messenger
  • Transcription Factors
  • Poly A