Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of children. Whereas adult sarcomas are mostly extremity tumors and rarely spread to regional nodes, RMS is ubiquitous, occurring almost everywhere in the body (most commonly in the head, neck, and genitourinary area), and frequently spreads to regional nodes (40% in extremity RMS). Survival has improved with each successive intragroup study, and surgical intervention, although integral for survival, is less mutilating.