Neurochemical correlates of dementia

Neurodegeneration. 1996 Dec;5(4):403-7. doi: 10.1006/neur.1996.0054.


Studies of the neurochemical pathology of AD have indicated that early in the course of the disease, abnormalities of relatively few neurotransmitters are obvious. The most reliable and consistent changes are those seen in the cholinergic innervation of the cortex and the cortical pyramidal neurones. However, by the time of death there is usually considerable involvement of other neurones.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Animals
  • Brain / metabolism*
  • Cerebral Cortex / metabolism
  • Cerebral Cortex / pathology
  • Humans
  • Parasympathetic Nervous System / metabolism
  • Pyramidal Cells / metabolism
  • Serotonin / metabolism


  • Serotonin