Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer disease

Neurodegeneration. 1996 Dec;5(4):473-6. doi: 10.1006/neur.1996.0065.


Reduced brain glucose utilization in early stages of Alzheimer disease, as measured with in vivo positron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / diagnostic imaging
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Brain / diagnostic imaging
  • Brain / metabolism*
  • Brain / physiopathology
  • Cognition*
  • Energy Metabolism*
  • Humans
  • Oxidative Phosphorylation*
  • Tomography, Emission-Computed