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, 53 (1), 114-21

Heat Shock Protein Gene Expression During Xenopus Development


Heat Shock Protein Gene Expression During Xenopus Development

J J Heikkila et al. Cell Mol Life Sci.


Stress-induced heat shock protein gene expression is developmentally regulated during early embryogenesis of the frog, Xenopus laevis. For example, a number of heat shock protein genes, such as hsp70, hsp90, and ubiquitin are not heat-inducible until after the midblastula stage of embryogenesis. Furthermore, the family of small heat shock protein genes, hsp30, are differentially expressed after the midblastula stage as well as being regulated at the level of mRNA stability. Many of these stress proteins are also synthesized constitutively during oogenesis and embryogenesis during which they may act as molecular chaperones as well as being involved in sequestering proteins in an inactive state until required by the developing embryo. Furthermore the induction of these stress protein genes has been correlated with enhanced thermoresistance. During stressful conditions heat shock proteins probably prevent aggregation or misfolding of damaged proteins within the embryo.

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