People are exposed to a mixture of chemicals, noise, bad smells and other factors. Little is known about the possible interactions between these various contaminants. Although research on the effects of chemical mixtures has been initiated, the combination of chemical and non-chemical factors has received little attention. This paper summarizes the possible effects of combined exposure to noise and the air pollutant ozone, which are both factors with a high prevalence in the Western society. A series of animal experiments are presented to evaluate the possible combined effects of noise and air pollution.