Isolated straight sinus and deep cerebral venous thrombosis: successful treatment with local infusion of urokinase. Case report

J Neurosurg. 1997 Apr;86(4):704-7. doi: 10.3171/jns.1997.86.4.0704.


A 23-year-old woman presented with headache and progressive lethargy. The diagnosis of isolated thrombosis of the straight sinus and of the deep cerebral venous system was established using cranial computerized tomography, magnetic resonance imaging, phase-contrast magnetic resonance venography, and cerebral angiography. Because of the rapid deterioration in the patient's clinical condition, the authors used direct transcatheter infusion of urokinase into the straight sinus. This treatment resulted in a successful outcome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Catheterization
  • Cerebral Angiography
  • Cerebral Veins* / diagnostic imaging
  • Cerebral Veins* / pathology
  • Cranial Sinuses* / diagnostic imaging
  • Cranial Sinuses* / pathology
  • Female
  • Humans
  • Infusions, Intravenous
  • Magnetic Resonance Imaging
  • Phlebography
  • Subtraction Technique
  • Thrombophlebitis / diagnosis
  • Thrombophlebitis / drug therapy*
  • Tomography, X-Ray Computed
  • Urokinase-Type Plasminogen Activator / administration & dosage*
  • Urokinase-Type Plasminogen Activator / therapeutic use


  • Urokinase-Type Plasminogen Activator