[Preparation and evaluation of solid dispersions of pilocarpine hydrochloride for alleviation of xerostomia]

Yakugaku Zasshi. 1997 Jan;117(1):59-64. doi: 10.1248/yakushi1947.117.1_59.
[Article in Japanese]


This investigation was carried out to try the application of pilocarpine hydrochloride (PC) solid dispersion as sustained release dosage form. Four preparations of PC with ethylcellulose and/or hydroxypropylmethylcellulose phthalate were prepared by the organic solvent method. The preparation D including PC: ethylcellulose: hydroxypropylmethylcellulose phthalate (1:9:10 at weight ratio) showed the best sustained release behavior in dissolution test among four preparations. The preparation D was examined by powder X-ray diffractometry and differential scanning calorimetry, and confirmed to be solid dispersion. Saliva secretory effect of preparation D was examined in healthy male volunteers, and its effect for Xerostomia was showed.

MeSH terms

  • Cellulose / analogs & derivatives
  • Delayed-Action Preparations
  • Dosage Forms
  • Humans
  • Hypromellose Derivatives
  • Male
  • Methylcellulose / analogs & derivatives
  • Pilocarpine / pharmacology*
  • Saliva / metabolism*
  • Stimulation, Chemical
  • Xerostomia / drug therapy*


  • Delayed-Action Preparations
  • Dosage Forms
  • Pilocarpine
  • Hypromellose Derivatives
  • ethyl cellulose
  • Cellulose
  • Methylcellulose