Low vascular density indicates poor response to radiotherapy in small glottic carcinomas

Pathol Res Pract. 1996 Nov;192(11):1090-4. doi: 10.1016/S0344-0338(96)80024-0.


Reportedly, the high density of vessels adjacent to various tumours is associated with increased tendency to metastasis and poor prognosis. In contrast, for other cancers a high vessel density is correlated with a good response to radiation therapy, and thus a good prognosis. In this study we measured the vessel density in 53 small glottic SCC (T1N0 and T2N0), treated with radiation (66-70 Gy). The blood vessels were visualised by an immunohistochemical staining method (ABC), using a primary antibody BE2 which reacts with blood group H antigen on endothelial cells. The intra- and interobserver reproducibility of the vessel counting was good (kappa = 0.78). We found a significant correlation between low vascular density and increased risk of recurrent disease (p = 0.0158). cox multivariate analysis showed that both vascular density and T-status were significant prognostic factors, p = 0.0036 and p = 0.0152 respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Vessels / pathology
  • Carcinoma / blood supply*
  • Carcinoma / pathology
  • Carcinoma / radiotherapy*
  • Female
  • Glottis*
  • Humans
  • Immunohistochemistry / methods
  • Laryngeal Neoplasms / blood supply*
  • Laryngeal Neoplasms / pathology
  • Laryngeal Neoplasms / radiotherapy*
  • Male
  • Middle Aged
  • Observer Variation
  • Prognosis
  • Proportional Hazards Models
  • Staining and Labeling