In vitro and in vivo effects of leflunomide, brequinar, and cyclosporine on pyrimidine biosynthesis

Transplant Proc. Feb-Mar 1997;29(1-2):1292-3. doi: 10.1016/s0041-1345(96)00523-4.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Biphenyl Compounds / antagonists & inhibitors
  • Biphenyl Compounds / pharmacology*
  • Cyclosporine / pharmacology*
  • Dihydroorotate Dehydrogenase
  • Heart Transplantation / immunology
  • Heart Transplantation / physiology*
  • Immunosuppressive Agents / pharmacology*
  • Isoxazoles / antagonists & inhibitors
  • Isoxazoles / pharmacology*
  • Leflunomide
  • Lymphocyte Activation / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Orotic Acid / pharmacology
  • Oxidoreductases / metabolism*
  • Oxidoreductases Acting on CH-CH Group Donors*
  • Pyrimidines / biosynthesis*
  • Rats
  • Transplantation, Homologous
  • Uridine / pharmacology

Substances

  • Biphenyl Compounds
  • Dihydroorotate Dehydrogenase
  • Immunosuppressive Agents
  • Isoxazoles
  • Pyrimidines
  • brequinar
  • Orotic Acid
  • Cyclosporine
  • Oxidoreductases
  • Oxidoreductases Acting on CH-CH Group Donors
  • Leflunomide
  • Uridine