A study of tolerance in a concordant xenograft model

Transplant Proc. Feb-Mar 1997;29(1-2):923-4. doi: 10.1016/s0041-1345(96)00236-9.

Abstract

Antibody-mediated rejection appears to constitute the major difference between concordant xenografts and allografts in nonhuman primates. Consistent with its known effect on antibody responses, 5-7 addition of DSG to the conditioning regimen has extended concordant primate xenograft survival for up to 6 months after discontinuation of conventional immunosuppression. In contrast to our observations in recipients of renal allografts, donor-specific skin graft rejection can occur and even in long-term recipients may induce rejection of a previously accepted renal xenograft.

MeSH terms

  • Animals
  • Antibodies, Heterophile / blood
  • Antibody Formation
  • Antilymphocyte Serum / therapeutic use
  • Bone Marrow Transplantation / immunology*
  • Cyclosporine / pharmacology
  • Graft Rejection / immunology*
  • Graft Survival
  • Guanidines / pharmacology
  • Immunity, Cellular
  • Immunoglobulin G / blood
  • Immunosuppression / methods
  • Immunosuppressive Agents / pharmacology
  • Kidney Transplantation / immunology*
  • Macaca fascicularis
  • Papio
  • Splenectomy
  • Thymus Gland / radiation effects
  • Transplantation, Heterologous / immunology*
  • Transplantation, Heterologous / pathology
  • Whole-Body Irradiation

Substances

  • Antibodies, Heterophile
  • Antilymphocyte Serum
  • Guanidines
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Cyclosporine
  • gusperimus