Recently, acute renal failure has often been managed with continuous extracorporeal detoxication of the blood. In this case detoxication unit worked for days or even weeks. The continuous detoxication (CD) has the advantages: no sharp homeostatic changes occur, blood detoxication covers the whole period of acute renal failure. Technical specifications of the equipment are provided, as well as the diseases most responding to CD and recommendations on anticoagulation and replacement of the lost amino acids and glucose. CD allows the physicians to adjust therapeutic scheme to current needs of the patient.