Antibodies to the chlamydial 60 kd heat-shock protein are associated with laparoscopically confirmed perihepatitis

Am J Obstet Gynecol. 1997 Apr;176(4):870-7. doi: 10.1016/s0002-9378(97)70613-6.


Objective: Our purpose was to examine clinical, microbiologic, serologic, and laparoscopic findings associated with perihepatitis.

Study design: In a prospective study of 157 women with a clinical diagnosis of pelvic inflammatory disease, 27 women with laparoscopically confirmed perihepatitis and salpingitis were compared with 46 patients with salpingitis alone.

Results: Both current use or a history of ever using oral contraceptives was negatively associated with perihepatitis (p = 0.05 and p = 0.008, respectively). Moderate-to-severe pelvic adhesions were present at laparoscopy significantly more often in the perihepatitis-salpingitis group (70%) than in the salpingitis alone group (35%, p = 0.003). Antibody to the chlamydial 60 kd heat-shock protein at > or =0.5 optical density was detected in 67% of the perihepatitis-salpingitis group and in 28% of the salpingitis alone group (p = 0.005), and the median titer was significantly higher in the former group (p = 0.02).

Conclusion: Compared with women with salpingitis alone, patients with perihepatitis-salpingitis do not have distinctive clinical or microbiologic findings but do manifest a higher prevalence of moderate-to-severe pelvic adhesions and both a higher prevalence and higher titers of antibody to the chlamydial heat-shock protein-60.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antibodies, Bacterial / blood*
  • Chaperonin 60 / immunology*
  • Chlamydia Infections / complications
  • Chlamydia trachomatis / immunology*
  • Chlamydia trachomatis / isolation & purification
  • Female
  • Hepatitis / complications
  • Hepatitis / immunology*
  • Hepatitis / microbiology
  • Humans
  • Neisseria gonorrhoeae / isolation & purification
  • Pelvis
  • Prospective Studies
  • Salpingitis / complications
  • Salpingitis / immunology*
  • Salpingitis / microbiology
  • Statistics, Nonparametric
  • Tissue Adhesions


  • Antibodies, Bacterial
  • Chaperonin 60