A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women

Clin Infect Dis. 1997 Feb;24 Suppl 2:S222-30. doi: 10.1093/clinids/24.supplement_2.s222.

Abstract

We conducted a multicenter trial to compare the efficacy and safety of meropenem with the efficacy and safety of clindamycin plus gentamicin in the treatment of 515 hospitalized patients with acute gynecologic and obstetric pelvic infections. At the end of treatment, the rates of satisfactory clinical and bacteriologic response were high (88%) in both treatment groups: the rates of response were 90% for the meropenem group and 86% for the clindamycin/gentamicin group. No serious adverse events occurred. The most frequently reported drug-related adverse clinical events in the meropenem group were nausea and injection-site reactions (> 1% of patients), and the most common drug-related laboratory abnormality was thrombocythemia. Similar patterns of adverse events occurred in the clindamycin/gentamicin group; however, the incidence of diarrhea and eosinophilia was higher in this group. In summary, this trial demonstrated that meropenem is an effective and safe alternative to the combination of clindamycin plus gentamicin for the treatment of women with acute gynecologic and obstetric pelvic infections.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteria / drug effects
  • Bacteria / isolation & purification
  • Bacterial Infections / diagnosis
  • Bacterial Infections / drug therapy*
  • Clindamycin / administration & dosage
  • Clindamycin / adverse effects
  • Clindamycin / therapeutic use*
  • Diarrhea / chemically induced
  • Drug Therapy, Combination
  • Eosinophilia / chemically induced
  • Female
  • Genital Diseases, Female / diagnosis
  • Genital Diseases, Female / drug therapy*
  • Genital Diseases, Female / microbiology*
  • Gentamicins / administration & dosage
  • Gentamicins / adverse effects
  • Gentamicins / therapeutic use*
  • Hospitalization
  • Humans
  • Meropenem
  • Microbial Sensitivity Tests
  • Pelvic Inflammatory Disease / diagnosis
  • Pelvic Inflammatory Disease / drug therapy*
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis
  • Pregnancy Complications, Infectious / drug therapy*
  • Pregnancy Complications, Infectious / microbiology*
  • Thienamycins / administration & dosage
  • Thienamycins / adverse effects
  • Thienamycins / therapeutic use*
  • Thrombocytopenia / chemically induced

Substances

  • Anti-Bacterial Agents
  • Gentamicins
  • Thienamycins
  • Clindamycin
  • Meropenem