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, 386 (6627), 804-10

Embryonic Lethality and Radiation Hypersensitivity Mediated by Rad51 in Mice Lacking Brca2

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Embryonic Lethality and Radiation Hypersensitivity Mediated by Rad51 in Mice Lacking Brca2

S K Sharan et al. Nature.

Abstract

Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2.

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