A longitudinal magnetic resonance imaging study of the cervical cord in multiple sclerosis

J Neuroimaging. 1997 Apr;7(2):78-80. doi: 10.1111/jon19977278.


This study was performed to evaluate the correlation between changes of cross-sectional cord area and disability in multiple sclerosis. Axial magnetic resonance images at the C-5 spinal level were obtained at entry and 12 months later for 29 patients with clinically definite multiple sclerosis. The degree of disability was inversely correlated at entry and follow-up with the cross-sectional area and the transverse diameter of the spinal cord. In addition, changes in disability correlated inversely with changes in cross-sectional area (r = -0.4, p = 0.04). These findings suggest that cross-sectional cord area at C-5 might be a useful marker of disease evolution.

MeSH terms

  • Adult
  • Disability Evaluation
  • Female
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Multiple Sclerosis / pathology*
  • Multiple Sclerosis / physiopathology
  • Spinal Cord / pathology*
  • Time Factors