Prognostic value of Ki-67 expression in renal cell carcinomas

Eur Urol. 1997;31(3):350-5. doi: 10.1159/000474482.


Objective: The aim of the study was to determine the prognostic power of Ki-67 immunostaining in renal cell carcinomas (RCC).

Methods: Clinical follow-up data were reviewed in 111 RCC and the results of Ki-67 immunolabelling were correlated to standard prognostic factors and survival data of the patients.

Results: Ki-67 expression correlated with tumor grade (p < 0.0001) and mitotic activity (p < 0.0001). In survival analysis Ki-67 expression could be used to divide patients into different prognostic groups (p = 0.0003). In separate analysis with M0 tumors Ki-67 immunolabelling was a powerful predictor of survival (p = 0.0016) as well as disease-free survival (DFS; p = 0.0067). In T1-2N0M0 tumors Ki-67 immunolabelling was superior (p = 0.0005) to other prognostic factors in survival analysis as well as in predicting DFS (p = 0.0006). Grade-2 tumors could be separated into distinct prognostic groups according to Ki-67 labelling (p = 0.0098). In Cox's multivariate analysis Ki-67 was an independent prognostic factor in all three subgroups of RCC.

Conclusions: The results show that Ki-67 expression is an independent prognostic factor in renal adenocarcinoma and could be applied in defining proper therapy for patients suffering from this malignancy.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Antibodies, Monoclonal / immunology
  • Antibody Formation
  • Antigen-Antibody Reactions
  • Carcinoma, Renal Cell / immunology*
  • Carcinoma, Renal Cell / metabolism
  • Carcinoma, Renal Cell / mortality
  • Cell Differentiation / immunology
  • Computer Simulation
  • Female
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen / analysis*
  • Ki-67 Antigen / immunology
  • Kidney Neoplasms / immunology*
  • Kidney Neoplasms / metabolism
  • Kidney Neoplasms / mortality
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prognosis
  • Survival Analysis


  • Antibodies, Monoclonal
  • Ki-67 Antigen