The human cytomegalovirus major immediate-early gene

Intervirology. 1996;39(5-6):343-9. doi: 10.1159/000150505.


Immediate-early genes function to regulate viral and cellular gene expression during the course of virus replication. The major immediate-early gene region of human cytomegalovirus plays a key role in affecting activation and repression of viral and cellular genes. These proteins intimately associate and/or interact with viral and cellular proteins during this process. Herein, we will discuss the current understanding of this complex gene region.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigens, Viral / genetics*
  • Cytomegalovirus / genetics*
  • Gene Expression Regulation, Viral
  • Genes, Viral*
  • Humans
  • Immediate-Early Proteins / genetics*
  • Membrane Glycoproteins*
  • Trans-Activators*
  • Viral Envelope Proteins*
  • Viral Proteins*


  • Antigens, Viral
  • IE1 protein, cytomegalovirus
  • IE2 protein, Cytomegalovirus
  • Immediate-Early Proteins
  • Membrane Glycoproteins
  • Trans-Activators
  • UL115 protein, Human herpesvirus 5
  • Viral Envelope Proteins
  • Viral Proteins
  • glycoprotein H, Cytomegalovirus
  • glycoprotein H, Human cytomegalovirus
  • glycoprotein O, cytomegalovirus
  • immediate-early proteins, cytomegalovirus