Post-radiation valvular and coronary artery disease

J Heart Valve Dis. 1997 Mar;6(2):219-21.


The authors report a case of mitro-aortic valvulopathy associated with single-vessel coronary disease, both probably caused by thoracic irradiation, initially for Hodgkin's lymphoma, and later for carcinoma of the breast. The patient was subjected to aortic valve replacement with a mechanical prosthesis, partial mitral annuloplasty and myocardial revascularization. This report underscores the importance of long-term follow up of patients subjected to mediastinal radiotherapy, because of the significant cardiac morbidity caused by this type of treatment.

Publication types

  • Case Reports

MeSH terms

  • Aortic Valve Insufficiency / etiology*
  • Aortic Valve Insufficiency / surgery
  • Breast Neoplasms / radiotherapy
  • Coronary Angiography
  • Coronary Artery Bypass
  • Coronary Disease / etiology*
  • Coronary Disease / surgery
  • Disease-Free Survival
  • Female
  • Heart Valve Prosthesis*
  • Hodgkin Disease / radiotherapy
  • Humans
  • Middle Aged
  • Mitral Valve Insufficiency / etiology*
  • Mitral Valve Insufficiency / surgery
  • Radiation Injuries / complications*
  • Radiation Injuries / diagnosis