Lymphocyte activation in allergic reactions elicited by small-molecular-weight compounds

Int Arch Allergy Immunol. 1997 May-Jul;113(1-3):173-6. doi: 10.1159/000237538.


The involvement of cytochrome-P450-dependent metabolism of small-molecular-weight compounds as a prerequisite for an optimal lymphocyte response to those compounds is discussed on the basis of studies with compound such as p-phenylenediamine, sulfamethoxazole, chloramphenicol and fragrances. Subsequently, data on cytochrome P450 activity and CYP gene expression in monocytes and MAC-6 cells for cytochromes P450 2E1 and 3A4 are presented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chloramphenicol / immunology
  • Cytochrome P-450 Enzyme System / physiology
  • Humans
  • Hypersensitivity / immunology*
  • Lymphocyte Activation*
  • Molecular Weight
  • Monocytes / enzymology
  • Phenylenediamines / immunology
  • Sulfonamides / immunology


  • Phenylenediamines
  • Sulfonamides
  • Chloramphenicol
  • Cytochrome P-450 Enzyme System
  • 4-phenylenediamine