Molecular mechanisms of defective eosinophil apoptosis in diseases associated with eosinophilia

Int Arch Allergy Immunol. May-Jul 1997;113(1-3):206-8. doi: 10.1159/000237548.

Abstract

Apoptosis is a necessary process to maintain correct cell numbers in a multicellular organism. Defects in this process may contribute to the pathogenesis of a number of human diseases. We have suggested that inhibition of apoptosis in eosinophils by cytokines such as IL-5 and GM-CSF may play an important role in the pathogenesis of allergic disorders. Here, we review our recent progress in understanding the processes regulating eosinophil apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis*
  • Eosinophilia / physiopathology*
  • Eosinophils / physiology*
  • Humans
  • Interleukin-5 / physiology
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / physiology
  • Signal Transduction
  • T-Lymphocytes / physiology

Substances

  • Interleukin-5
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor