Growth in the diabetic child

Pediatr Clin North Am. 1997 Apr;44(2):301-6. doi: 10.1016/s0031-3955(05)70478-8.

Abstract

Insulin has an important role in the GH:IGF-I axis, and its absence leads to major endocrine disturbances, particularly during puberty. Rapid growth in the prediabetic phase occurs and may be a risk factor. Final height reflects gender and the age of onset more than specific growth factors. The influence of hepatic insulin on IGF-I bioactivity has important implications in diabetic adolescents.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Age of Onset
  • Body Height
  • Child
  • Diabetes Mellitus, Type 1 / complications*
  • Growth Disorders / etiology*
  • Growth Hormone / physiology
  • Humans
  • Insulin-Like Growth Factor I / physiology
  • Puberty
  • Risk Factors
  • Sex Characteristics

Substances

  • Insulin-Like Growth Factor I
  • Growth Hormone