Solvents and neurotoxicity

Lancet. 1997 Apr 26;349(9060):1239-43. doi: 10.1016/S0140-6736(96)07218-2.


We describe the clinical evaluation of the nervous-system effects of solvent exposure. We review the current evidence in the epidemiological literature on neurotoxicological effects of solvents, and outline methods and issues to be taken into account in assessment of the patient whose symptoms may be related to solvent toxicity. Primary prevention of these disorders is essential, because treatment options are limited.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Central Nervous System Diseases / chemically induced
  • Cognition Disorders / chemically induced
  • Humans
  • Mental Disorders / chemically induced
  • Middle Aged
  • Nervous System Diseases / chemically induced*
  • Nervous System Diseases / diagnosis
  • Nervous System Diseases / epidemiology
  • Nervous System Diseases / prevention & control
  • Nervous System Diseases / therapy
  • Occupational Diseases / chemically induced
  • Occupational Exposure
  • Peripheral Nervous System Diseases / chemically induced
  • Solvents / adverse effects*
  • Solvents / classification


  • Solvents